Multi-omics approach to decipher the chromatin and transcriptional landscape of fasting Frame work: The PhD candidate will work with a highly motivated team in the research group of Andreas Prokesch at the Medical University of Graz (MUG) in Austria. The MUG provides an interdisciplinary environment with a strong life science research focus, underscored by the existence of three research centers and eight core facilities. Embedded in the Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, the group is well connected at the MUG (also with clinical researchers), with local universities, and has a strong international research network (collaborations with Germany, USA, France, Spain, Netherlands, Italy). The PhD thesis will be conducted within the frame of the PhD program Molecular Medicine offering a strong life science curriculum (in English), an annual DocDay symposium, and extracurricular activities. Project topic: While the long-term health benefits of periodic fasting are well known, the underlying cellular and molecular mechanisms remain largely enigmatic. The PhD candidate will work on a project that seeks to identify fasting-mediated molecular mechanisms through analysis of datasets from state-of-the-art next-generation sequencing methods (PRO-seq, ATAC-seq, single cell RNA-seq). We aim to explore how the transcriptional and epigenetic landscapes change during fasting and how this correlates with long-term beneficial effects of fasting. In addition to elucidating the underlying molecular mechanisms, detailed bioinformatics analyses will aid in the discovery of potential biomarkers and therapeutic targets related to fasting.